ATP-Dependent Translocase ABCB1 (ABCB1) Antibody
351€ (100 µg)
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935106861
info@markelab.com
name
ATP-Dependent Translocase ABCB1 (ABCB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx414457
tested applications
IHC, IF/ICC, FCM, IP
Description
ATP Binding Cassette Subfamily B Member 1 (ABCB1) Antibody is a Mouse Monoclonal antibody against CD243.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-Dependent Translocase ABCB1 (ABCB1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-F and IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | IHC, IF/ICC, FCM, IP |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08183 |
| Alias | ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170 |
| Background | Antibody anti-ABCB1 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.
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