ATP Binding Cassette Transporter C8 (ABCC8) Antibody (ATTO488)
637€ (100 µg)
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935106861
info@markelab.com
name
ATP Binding Cassette Transporter C8 (ABCC8) Antibody (ATTO488)
category
Primary Antibodies
provider
Abbexa
reference
abx440450
tested applications
WB, IHC, IF/ICC
Description
ATP Binding Cassette Transporter C8 (ABCC8) Antibody is a Mouse Monoclonal against ATP Binding Cassette Transporter C8 (ABCC8).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter C8 (ABCC8) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat, Hamster |
| Recommended Dilution | WB: 1/1000, IHC: 1/1000, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | ATTO488 |
| Isotype | IgG1 |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q09429 |
| Gene ID | 25559 |
| NCBI Accession | NP_037171.2 |
| Alias | ABC36,HHF1,HI,HRINS,MRP8,PHHI,PNDM3 |
| Background | Antibody anti-ABCC8 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ATP Binding Cassette Subfamily C Member 8 (ABCC8) encodes a sulfonylurea receptor that functions as a regulatory subunit of ATP-sensitive potassium (K-ATP) channels. These channels play a critical role in glucose-induced insulin secretion in pancreatic beta cells by coupling metabolic signals to membrane depolarization. ABCC8 mutations are linked to congenital hyperinsulinism, a condition characterized by unregulated insulin secretion leading to hypoglycemia. The protein is also expressed in cardiac and skeletal muscle tissues, where it regulates cellular energy homeostasis and membrane excitability under metabolic stress. Pharmacologically, ABCC8 is targeted by sulfonylureas and meglitinides, drugs used to treat type 2 diabetes by stimulating insulin secretion. Research highlights its potential role in cardiovascular physiology, particularly in ischemic preconditioning, where it helps protect tissues during periods of low oxygen supply.
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