ATP Binding Cassette Transporter C8 (ABCC8) Antibody (APC)
637€ (100 µg)
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Name
ATP Binding Cassette Transporter C8 (ABCC8) Antibody (APC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx442698
Tested Applications
WB, IHC, IF/ICC
Description
ATP Binding Cassette Transporter C8 (ABCC8) Antibody is a Mouse Monoclonal against ATP Binding Cassette Transporter C8 (ABCC8).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ATP Binding Cassette Transporter C8 (ABCC8) Immunogen: Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1. |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat, Hamster |
| Detection Method | Laser Line: 647 Excitation/Emission: 651/660 |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/1000, IHC: 1/1000, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG1 |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at 4°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q09429 |
| Gene ID | 25559 |
| NCBI Accession | NP_037171.2 |
| Alias | ABC36,HHF1,HI,HRINS,MRP8,PHHI,PNDM3 |
| Background | Antibody anti-ABCC8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ATP Binding Cassette Subfamily C Member 8 (ABCC8) encodes a sulfonylurea receptor that functions as a regulatory subunit of ATP-sensitive potassium (K-ATP) channels. These channels play a critical role in glucose-induced insulin secretion in pancreatic beta cells by coupling metabolic signals to membrane depolarization. ABCC8 mutations are linked to congenital hyperinsulinism, a condition characterized by unregulated insulin secretion leading to hypoglycemia. The protein is also expressed in cardiac and skeletal muscle tissues, where it regulates cellular energy homeostasis and membrane excitability under metabolic stress. Pharmacologically, ABCC8 is targeted by sulfonylureas and meglitinides, drugs used to treat type 2 diabetes by stimulating insulin secretion. Research highlights its potential role in cardiovascular physiology, particularly in ischemic preconditioning, where it helps protect tissues during periods of low oxygen supply.
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