ATP Binding Cassette Transporter C8 (ABCC8) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
ATP Binding Cassette Transporter C8 (ABCC8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx242539
tested applications
ELISA, IHC
Description
ATP Binding Cassette Transporter C8 (ABCC8) Antibody is a Rabbit Polyclonal against ATP Binding Cassette Transporter C8 (ABCC8).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter C8 (ABCC8) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/35 - 1/150. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q09428 |
| Gene ID | 6833 |
| Alias | ABC36,HHF1,HI,HRINS,MRP8,PHHI,PNDM3 |
| Background | Antibody anti-ABCC8 |
| Status | RUO |
Descripción
ATP Binding Cassette Subfamily C Member 8 (ABCC8) encodes a sulfonylurea receptor that functions as a regulatory subunit of ATP-sensitive potassium (K-ATP) channels. These channels play a critical role in glucose-induced insulin secretion in pancreatic beta cells by coupling metabolic signals to membrane depolarization. ABCC8 mutations are linked to congenital hyperinsulinism, a condition characterized by unregulated insulin secretion leading to hypoglycemia. The protein is also expressed in cardiac and skeletal muscle tissues, where it regulates cellular energy homeostasis and membrane excitability under metabolic stress. Pharmacologically, ABCC8 is targeted by sulfonylureas and meglitinides, drugs used to treat type 2 diabetes by stimulating insulin secretion. Research highlights its potential role in cardiovascular physiology, particularly in ischemic preconditioning, where it helps protect tissues during periods of low oxygen supply.
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