ATP Binding Cassette Transporter C5 (ABCC5) Antibody (HRP)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
ABCC5 Antibody (HRP) is a Rabbit Polyclonal against ABCC5.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter C5 (ABCC5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15440 |
| Gene ID | 10057 |
| Alias | ABC33,EST277145,MOAT-C,MOATC |
| Background | Antibody anti-ABCC5 |
| Status | RUO |
Descripción
ATP Binding Cassette Subfamily C Member 5 (ABCC5), also known as multidrug resistance-associated protein 5 (MRP5), plays a crucial role in the transport of various substrates across cellular membranes. This protein is part of the ATP-binding cassette (ABC) transporter family and utilizes ATP hydrolysis to facilitate the export of organic anions and cyclic nucleotides like cGMP and cAMP from cells. ABCC5 is expressed in multiple tissues, including the liver, kidneys, and brain, where it contributes to cellular detoxification and protection against xenobiotics and endogenous metabolites. Furthermore, ABCC5 is implicated in drug resistance, particularly in cancer therapy, by actively exporting chemotherapeutic agents, thereby reducing their intracellular accumulation. Research also suggests its role in regulating vascular smooth muscle tone and platelet aggregation, highlighting its physiological significance beyond drug transport. Polymorphisms in ABCC5 may influence individual variability in drug responses and susceptibility to certain diseases, making it a target of interest for pharmacogenomics.
Related Products
Human ABCC5(ATP Binding Cassette Transporter C5) ELISA Kit
Ver Producto
ATP Binding Cassette Transporter C5 (ABCC5) Antibody
ABCC5 Antibody is a Rabbit Polyclonal antibody against ABCC5. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine.
Ver Producto
Human ATP Binding Cassette Transporter C5 (ABCC5) ELISA Kit
Human ATP Binding Cassette Transporter C5 (ABCC5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ATP Binding Cassette Transporter C5 (ABCC5) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of ATP Binding Cassette Transporter C5 (ABCC5)
Ver Producto