Human ABCC5 (ATP Binding Cassette Transporter C5) ELISA Kit
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Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 78.125-5000pg/ml |
| Sensitivity | 46.875pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O15440 |
| Alias | ABC33,EST277145,MOAT-C,MOATC |
| Background | Elisa kits for ABCC5 |
| Status | RUO |
ATP Binding Cassette Subfamily C Member 5 (ABCC5), also known as multidrug resistance-associated protein 5 (MRP5), plays a crucial role in the transport of various substrates across cellular membranes. This protein is part of the ATP-binding cassette (ABC) transporter family and utilizes ATP hydrolysis to facilitate the export of organic anions and cyclic nucleotides like cGMP and cAMP from cells. ABCC5 is expressed in multiple tissues, including the liver, kidneys, and brain, where it contributes to cellular detoxification and protection against xenobiotics and endogenous metabolites. Furthermore, ABCC5 is implicated in drug resistance, particularly in cancer therapy, by actively exporting chemotherapeutic agents, thereby reducing their intracellular accumulation. Research also suggests its role in regulating vascular smooth muscle tone and platelet aggregation, highlighting its physiological significance beyond drug transport. Polymorphisms in ABCC5 may influence individual variability in drug responses and susceptibility to certain diseases, making it a target of interest for pharmacogenomics.
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ABCC5 Antibody is a Rabbit Polyclonal antibody against ABCC5. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine.
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