ATP Binding Cassette Transporter C10 (ABCC10) Antibody
357.5€ (100 µg)
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935106861
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name
ATP Binding Cassette Transporter C10 (ABCC10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037660
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the ABCC10 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter C10 (ABCC10) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_258261 |
| Alias | EST182763,MRP7,SIMRP7 |
| Background | Antibody anti-ABCC10 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ATP-binding cassette subfamily C member 10 (ABCC10), also known as multidrug resistance-associated protein 7 (MRP7), is part of the ABC transporter family involved in ATP-dependent efflux of endogenous and exogenous compounds across cellular membranes. ABCC10 plays a role in multidrug resistance by transporting chemotherapeutic agents such as taxanes and nucleoside analogs. It is widely expressed in various tissues, including the liver, lungs, and intestines, contributing to detoxification and xenobiotic metabolism. The protein contains two transmembrane domains and two nucleotide-binding domains, characteristic of ABC transporters. Dysregulation or overexpression of ABCC10 is associated with cancer drug resistance and altered pharmacokinetics of therapeutic agents.
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