ATP Binding Cassette Transporter B4 (ABCB4) Antibody
286€ (100 µl)
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935106861
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name
ATP Binding Cassette Transporter B4 (ABCB4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130561
tested applications
WB, IHC, IF/ICC
Description
ATP Binding Cassette Transporter B4 (ABCB4) Antibody is a Rabbit Polyclonal against ATP Binding Cassette Transporter B4 (ABCB4).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter B4 (ABCB4) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21440 |
| Gene ID | 18670 |
| Alias | ABC21,GBD1,ICP3,MDR2,MDR2/3,MDR3,PFIC-3,PGY3 |
| Background | Antibody anti-ABCB4 |
| Status | RUO |
Descripción
ABCB4, also known as MDR3, is expressed on the canalicular membrane of hepatocytes and plays a pivotal role in bile formation by mediating the ATP-dependent translocation of phosphatidylcholine into bile. Phosphatidylcholine protects bile ducts from the detergent effects of bile salts, ensuring proper bile composition and preventing bile-related liver damage. Mutations in ABCB4 are associated with progressive familial intrahepatic cholestasis type 3 (PFIC3), low phospholipid-associated cholelithiasis (LPAC), and other cholestatic liver diseases. Dysregulation of ABCB4 leads to bile duct injury, inflammation, and fibrosis, ultimately resulting in liver dysfunction. As a critical regulator of bile composition, ABCB4 is a significant focus in the study of liver health and diseases related to bile metabolism.
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