ATP Binding Cassette Transporter B4 (ABCB4) Antibody

286€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
ATP Binding Cassette Transporter B4 (ABCB4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130561
tested applications
WB, IHC, IF/ICC
Description
ATP Binding Cassette Transporter B4 (ABCB4) Antibody is a Rabbit Polyclonal against ATP Binding Cassette Transporter B4 (ABCB4).
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | ATP Binding Cassette Transporter B4 (ABCB4) |
Host | Rabbit |
Reactivity | Mouse |
Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
Size 1 | 100 µl |
Size 2 | 200 µl |
Size 3 | 1 ml |
Form | Liquid |
Tested Applications | WB, IHC, IF/ICC |
Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
Availability | Shipped within 5-7 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P21440 |
Gene ID | 18670 |
Alias | ABC21,GBD1,ICP3,MDR2,MDR2/3,MDR3,PFIC-3,PGY3 |
Background | Antibody anti-ABCB4 |
Status | RUO |
Descripción
ABCB4, also known as MDR3, is expressed on the canalicular membrane of hepatocytes and plays a pivotal role in bile formation by mediating the ATP-dependent translocation of phosphatidylcholine into bile. Phosphatidylcholine protects bile ducts from the detergent effects of bile salts, ensuring proper bile composition and preventing bile-related liver damage. Mutations in ABCB4 are associated with progressive familial intrahepatic cholestasis type 3 (PFIC3), low phospholipid-associated cholelithiasis (LPAC), and other cholestatic liver diseases. Dysregulation of ABCB4 leads to bile duct injury, inflammation, and fibrosis, ultimately resulting in liver dysfunction. As a critical regulator of bile composition, ABCB4 is a significant focus in the study of liver health and diseases related to bile metabolism.
Related Products

Human ABCB4 (Multidrug resistance protein 3) ELISA Kit
Ver Producto
Human ABCB4 (Multidrug resistance protein 3) QuickTest ELISA Kit
Ver Producto
ATP Binding Cassette Transporter B4 (ABCB4) Antibody (Biotin)
ATP Binding Cassette Transporter B4 (ABCB4) Antibody (Biotin) is a Rabbit Polyclonal antibody against ATP Binding Cassette Transporter B4 (ABCB4) conjugated to Biotin.
Ver Producto