ATP Binding Cassette Transporter A6 (ABCA6) Antibody

Background

ABCA6 is an ATP-binding cassette transporter that is thought to be involved in lipid metabolism and cholesterol transport, although its exact substrates and physiological roles are not fully characterized. It is primarily expressed in tissues such as the liver, macrophages, and vascular endothelial cells, where it may participate in lipid efflux and reverse cholesterol transport. ABCA6 shares structural similarities with other members of the ABCA subfamily, containing two transmembrane domains and two nucleotide-binding domains that facilitate ATP-driven substrate translocation. Dysregulation of ABCA6 expression has been associated with metabolic syndromes and cardiovascular diseases, suggesting its involvement in lipid-related disorders. Further research is needed to elucidate its specific functions in cellular lipid handling and disease progression.