Glucosylceramide Transporter ABCA12 (ABCA12) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Glucosylceramide Transporter ABCA12 (ABCA12) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx334747
Description
ABCA12 Antibody (FITC) is a Rabbit Polyclonal against ABCA12.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glucosylceramide Transporter ABCA12 (ABCA12) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86UK0 |
| Gene ID | 26154 |
| Alias | ARCI4A,ARCI4B,ICR2B,LI2 |
| Background | Antibody anti-ABCA12 |
| Status | RUO |
Descripción
ABCA12 (ATP-binding cassette sub-family A member 12) is a member of the ATP-binding cassette (ABC) transporter superfamily, which is responsible for translocating a wide variety of molecules across cellular membranes. ABCA12 is crucial for the proper transport of lipids, particularly glucosylceramides, in the epidermis. These lipids play an essential role in forming the skin’s barrier function, protecting against environmental insults and preventing water loss. ABCA12 is highly expressed in keratinocytes within the epidermis, particularly in the granular layer, where it facilitates the secretion of lipids into lamellar bodies. These organelles are essential for maintaining the integrity of the stratum corneum, the outermost layer of the skin. Dysregulation or mutations in the ABCA12 gene can result in severe skin disorders, most notably Harlequin ichthyosis (HI), a rare but devastating congenital condition.
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