ATP Binding Cassette Subfamily B Member 4 (ABCB4) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
ATP Binding Cassette Subfamily B Member 4 (ABCB4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx135779
tested applications
WB
Description
ABCB4 Antibody is a Rabbit Polyclonal against ABCB4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily B Member 4 (ABCB4) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21439 |
| Gene ID | 5244 |
| NCBI Accession | NP_061337.1 |
| Alias | ABC21,GBD1,ICP3,MDR2,MDR2/3,MDR3,PFIC-3,PGY3 |
| Background | Antibody anti-ABCB4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ABCB4, also known as MDR3, is expressed on the canalicular membrane of hepatocytes and plays a pivotal role in bile formation by mediating the ATP-dependent translocation of phosphatidylcholine into bile. Phosphatidylcholine protects bile ducts from the detergent effects of bile salts, ensuring proper bile composition and preventing bile-related liver damage. Mutations in ABCB4 are associated with progressive familial intrahepatic cholestasis type 3 (PFIC3), low phospholipid-associated cholelithiasis (LPAC), and other cholestatic liver diseases. Dysregulation of ABCB4 leads to bile duct injury, inflammation, and fibrosis, ultimately resulting in liver dysfunction. As a critical regulator of bile composition, ABCB4 is a significant focus in the study of liver health and diseases related to bile metabolism.
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