ATP Binding Cassette Subfamily B Member 10 (ABCB10) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
ATP Binding Cassette Subfamily B Member 10 (ABCB10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032687
tested applications
ELISA, WB, IHC
Description
The membrane-associated protein ABCB10 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Subfamily B Member 10 (ABCB10) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000 - 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NRK6 |
| Alias | M-ABC2,MTABC2,EST20237 |
| Background | Antibody anti-ABCB10 |
| Status | RUO |
Descripción
ABCB10, also known as mitochondrial ABC transporter-2, is primarily localized in the inner mitochondrial membrane and plays a critical role in mitochondrial function and heme biosynthesis. It is involved in transporting substrates required for heme production, a vital component of hemoglobin and cytochromes. ABCB10 works in coordination with other mitochondrial transporters, such as ABCB7, to ensure proper iron-sulfur cluster biogenesis and cellular redox balance. It is highly expressed in tissues with high metabolic and oxygen demands, such as the liver, heart, and erythroid cells. Dysregulation of ABCB10 has been linked to mitochondrial dysfunction and oxidative stress, contributing to conditions such as anemia and cardiovascular diseases. Its role in maintaining mitochondrial health highlights its importance in cellular energy metabolism.
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