Arylacetamide Deacetylase-Like 1 (AADACL1) Antibody
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Description
Arylacetamide Deacetylase-Like 1 Antibody is a Rabbit Polyclonal antibody against Arylacetamide Deacetylase-Like 1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Arylacetamide Deacetylase-Like 1 (AADACL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6PIU2 |
| Gene ID | 57552 |
| NCBI Accession | NP_001139748.1 |
| OMIM | 613234 |
| Alias | NCEH1,AADACL1,NCEH, Arylacetamide deacetylase like 1 |
| Background | Antibody anti-NCEH1 |
| Status | RUO |
Descripción
Neutral cholesterol ester hydrolase 1 (NCEH1) is an enzyme involved in the hydrolysis of cholesterol esters into free cholesterol and fatty acids, playing a critical role in cholesterol metabolism and homeostasis. It is primarily localized in the cytosol and is highly expressed in tissues such as the liver, macrophages, and adrenal glands, where cholesterol metabolism is vital. NCEH1 contributes to the regulation of intracellular cholesterol levels and is involved in processes such as lipid droplet mobilization and reverse cholesterol transport. It also plays a significant role in foam cell formation in atherosclerotic plaques, highlighting its involvement in cardiovascular disease. Dysregulation or mutations in NCEH1 have been linked to lipid metabolism disorders and increased susceptibility to atherosclerosis, making it a potential therapeutic target for modulating cholesterol homeostasis and reducing cardiovascular risk.
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