NCEH1 antibody
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Description
AADACL1(Arylacetamide deacetylase-like 1) is also named as NCEH1, KIAA1363 and belongs to the 'GDXG' lipolytic enzyme family. The transmembrane enzyme, AADACL1, controls the production of the monoalkylglycerol ether(MAGE) class of NELs in cancer cells and acts as a 2-acetyl MAGE hydrolase and is likely the principal source for this activity in tumor cells(PMID:21513884). The full length protein has three glycosylation sites and can be N-glycosylated(PMID:19159218). It has 3 isoforms produced by alternative splicing.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | arylacetamide deacetylase-like 1 (NCEH1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50-55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP,IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6PIU2 |
| Alias | NCEH1,AADACL1,NCEH, Arylacetamide deacetylase like 1 |
| Background | Antibody anti-NCEH1 |
| Status | RUO |
| Note | Mol. Weight 50-55 kDa |
Descripción
Neutral cholesterol ester hydrolase 1 (NCEH1) is an enzyme involved in the hydrolysis of cholesterol esters into free cholesterol and fatty acids, playing a critical role in cholesterol metabolism and homeostasis. It is primarily localized in the cytosol and is highly expressed in tissues such as the liver, macrophages, and adrenal glands, where cholesterol metabolism is vital. NCEH1 contributes to the regulation of intracellular cholesterol levels and is involved in processes such as lipid droplet mobilization and reverse cholesterol transport. It also plays a significant role in foam cell formation in atherosclerotic plaques, highlighting its involvement in cardiovascular disease. Dysregulation or mutations in NCEH1 have been linked to lipid metabolism disorders and increased susceptibility to atherosclerosis, making it a potential therapeutic target for modulating cholesterol homeostasis and reducing cardiovascular risk.
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