ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1 (AGAP1) Antibody
260€ (50 µl)
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Name
ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1 (AGAP1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx213225
Tested Applications
ELISA, WB, IHC
Description
AGAP1 Antibody is a Rabbit Polyclonal against AGAP1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1 (AGAP1) Immunogen: Synthetic peptide of human AGAP1. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UPQ3 |
| Gene ID | 116987 |
| Alias | AGAP-1,CENTG2,GGAP1 |
| Background | Antibody anti-AGAP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AGAP1 is a multifunctional protein involved in regulating endocytic trafficking, cytoskeletal organization, and intracellular signaling. It acts as a GTPase-activating protein (GAP) for Arf family GTPases, facilitating vesicle formation and receptor recycling. Structurally, it contains a GTPase domain, ankyrin repeats for protein-protein interactions, and a PH (pleckstrin homology) domain that enables membrane association. AGAP1 is expressed in various tissues, with high levels in neurons, where it modulates synaptic vesicle trafficking, dendritic spine morphogenesis, and endosomal sorting. Dysregulation of AGAP1 has been linked to neurodevelopmental disorders, cognitive impairments, and cellular transport defects, emphasizing its critical role in neuronal connectivity and function.
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