ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1 (AGAP1) Antibody

Background

AGAP1 is a multifunctional protein involved in regulating endocytic trafficking, cytoskeletal organization, and intracellular signaling. It acts as a GTPase-activating protein (GAP) for Arf family GTPases, facilitating vesicle formation and receptor recycling. Structurally, it contains a GTPase domain, ankyrin repeats for protein-protein interactions, and a PH (pleckstrin homology) domain that enables membrane association. AGAP1 is expressed in various tissues, with high levels in neurons, where it modulates synaptic vesicle trafficking, dendritic spine morphogenesis, and endosomal sorting. Dysregulation of AGAP1 has been linked to neurodevelopmental disorders, cognitive impairments, and cellular transport defects, emphasizing its critical role in neuronal connectivity and function.