ArfGAP With FG Repeats 1 (AGFG1) Antibody

Background

AGFG1 is a cytoplasmic protein that plays a key role in intracellular trafficking and RNA transport. It contains an Arf-GAP domain, which facilitates the regulation of small GTPases involved in vesicle formation, and FG repeats, which mediate interactions with nuclear pore complexes and RNA-binding proteins. AGFG1 is highly expressed in tissues such as the brain, immune cells, and reproductive tissues, where it participates in mRNA transport and localization. It is also involved in the HIV life cycle, specifically in the nuclear export of viral RNA, making it a potential therapeutic target for antiviral strategies. Dysregulation of AGFG1 has been associated with disruptions in intracellular transport and immune signaling, with emerging evidence suggesting its involvement in diseases such as viral infections and possibly cancer.