ArfGAP With FG Repeats 1 (AGFG1) Antibody
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Description
AGFG1 Antibody is a Rabbit Polyclonal antibody against AGFG1. The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ArfGAP With FG Repeats 1 (AGFG1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P52594 |
| Gene ID | 3267 |
| NCBI Accession | NP_004495.2 |
| Alias | HRB,RAB,RIP |
| Background | Antibody anti-AGFG1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
AGFG1 is a cytoplasmic protein that plays a key role in intracellular trafficking and RNA transport. It contains an Arf-GAP domain, which facilitates the regulation of small GTPases involved in vesicle formation, and FG repeats, which mediate interactions with nuclear pore complexes and RNA-binding proteins. AGFG1 is highly expressed in tissues such as the brain, immune cells, and reproductive tissues, where it participates in mRNA transport and localization. It is also involved in the HIV life cycle, specifically in the nuclear export of viral RNA, making it a potential therapeutic target for antiviral strategies. Dysregulation of AGFG1 has been associated with disruptions in intracellular transport and immune signaling, with emerging evidence suggesting its involvement in diseases such as viral infections and possibly cancer.
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AGFG1 Antibody is a Rabbit Polyclonal antibody against AGFG1. The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene.
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