AGFG1 antibody
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Description
Required for vesicle docking or fusion during acrosome biogenesis(By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ArfGAP with FG repeats 1 (AGFG1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 58 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P52594 |
| Gene ID | 3267 |
| Alias | HRB,RAB,RIP |
| Background | Antibody anti-AGFG1 |
| Status | RUO |
| Note | Mol. Weight 58 kDa |
Descripción
AGFG1 is a cytoplasmic protein that plays a key role in intracellular trafficking and RNA transport. It contains an Arf-GAP domain, which facilitates the regulation of small GTPases involved in vesicle formation, and FG repeats, which mediate interactions with nuclear pore complexes and RNA-binding proteins. AGFG1 is highly expressed in tissues such as the brain, immune cells, and reproductive tissues, where it participates in mRNA transport and localization. It is also involved in the HIV life cycle, specifically in the nuclear export of viral RNA, making it a potential therapeutic target for antiviral strategies. Dysregulation of AGFG1 has been associated with disruptions in intracellular transport and immune signaling, with emerging evidence suggesting its involvement in diseases such as viral infections and possibly cancer.
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