Apolipoprotein L (APOL1) Antibody
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Description
APOL1 (apolipoprotein L, 1), also known as APOL, APO-L, APOL-I.Entrez Protein NP_001130012.It is a 395aa secreted high density lipoprotein which binds to apolipoprotein A-I.And is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells.The apolipoprotein L gene family encodes six highly homologous proteins designated apoL-I to -VI.This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver.Several different transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apolipoprotein L (APOL1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14791 |
| Gene ID | 8542 |
| OMIM | 603743 |
| Alias | APOL1, APO-L, APOL, APOL-I, FSGS4, apolipoprotein L1, APO L1 |
| Background | Antibody anti-APOL1 |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
Apolipoprotein L1 (APOL1) is a member of the Apolipoprotein L gene family and plays a critical role in lipid transport and innate immunity. APOL1 is primarily expressed in the liver, kidney, and vascular endothelium and is known for its ability to bind high-density lipoprotein (HDL) particles, contributing to lipid transport and cholesterol metabolism. A particularly vital function of APOL1 lies in its role in innate immunity, as it helps protect against trypanosome infections. APOL1 can lyse trypanosomes such as Trypanosoma brucei, which cause African sleeping sickness, by disrupting their cellular membranes. Genetic variations, specifically the G1 and G2 risk alleles, have been associated with increased susceptibility to kidney diseases, such as focal segmental glomerulosclerosis (FSGS) and HIV-associated nephropathy (HIVAN), particularly in people of African descent. These alleles enhance APOL1-mediated trypanosome resistance but lead to cytotoxic effects in kidney cells under specific stress conditions. APOL1’s dual role as both a defender against pathogens and a contributor to renal disease makes it a subject of intensive research. Targeting APOL1 signaling pathways may provide therapeutic options for managing kidney diseases and understanding its broader impact on lipid metabolism and immune responses.
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This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.
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May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
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