Family main features
Apolipoprotein L1 (APOL1) is a protein encoded by the APOL1 gene in humans. It plays a significant role in lipid metabolism and innate immunity. The APOL1 gene has been associatied to certain kidney diseases, particularly in individuals of African descent. Variants in the APOL1 gene are strongly linked to an increased risk of chronic kidney disease (CKD) and end-stage renal disease (ESRD) The two most common variants associated with kidney disease are G1 and G2. These variants are found almost exclusively in people with recent African ancestry and are thought to have arisen as a defense mechanism against African sleeping sickness, caused by the parasite Trypanosoma brucei rhodesiense. However, these variants also increase susceptibility to certain forms of kidney disease. The exact mechanisms by which APOL1 variants lead to kidney damage are not fully understood. However, research suggests that the expression of APOL1 G1 and G2 variants in kidney cells can lead to cell injury and death, ultimately contributing to the development of kidney disease.The presence of APOL1 risk variants is associated with an increased risk of kidney disease progression and poorer outcomes in individuals with CKD or other kidney disorders. Understanding a patient's APOL1 genotype can help clinicians better assess their risk of kidney disease and tailor treatment strategies accordingly.
APOL1 is part of the apolipoprotein L family, which includes several other apolipoproteins with similar functions. There are different isoforms of APOL1 resulting from alternative splicing, but the most studied variants are related to the gene's polymorphisms.
Apolipoprotein L1 (APOL1) is a crucial protein involved in lipid transport, immune response, and kidney function. It is a component of HDL particles and plays a role in cholesterol homeostasis and protection against trypanosome infections. Genetic variants of APOL1 are linked to an increased risk of kidney diseases, particularly in individuals of African descent. Understanding APOL1's functions and interactions is essential for developing therapeutic strategies for kidney diseases and exploring its role in cardiovascular health and immune protection.
Apolipoprotein L (APOL1)
APOL1, APO-L, APOL, APOL-I, FSGS4, apolipoprotein L1, APO L1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con APOL1 - Apolipoprotein L1
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Esta página contiene 33 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | APOL1 | EH1181 | Human APOL1(Apolipoprotein L1) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.781-50ng/ml | 96T | O14791 | RUO | ||
Abbexa | APOL1 | abx150720 | Human Apolipoprotein L (APOL1) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 1.25 ng/ml - 80 ng/ml | < 0.51 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | APOL1 | abx250434 | Human Apolipoprotein L (APOL1) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | 0.94 ng/ml | 556.25 | 96 tests | O14791 | RUO |
Abbexa | APOL1 | abx573227 | Human Apolipoprotein L (APOL1) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 0.47 ng/ml | 556.25 | 96 tests | RUO | |
Abbexa | APOL1 | abx494362 | Human Apolipoprotein L (APOL1) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 1.25 ng/ml - 80 ng/ml | < 0.54 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | APOL1 | abx258396 | Human High Sensitive Apolipoprotein L (APOL1) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | APOL1 | abx258787 | Mouse Apolipoprotein L (APOL1) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.14 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | APOL1 | abx496432 | Mouse Apolipoprotein L (APOL1) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.133 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | APOL1 | abx585115 | Rat Apolipoprotein L (APOL1) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 15.6 pg/ml - 1000 pg/ml | < 7.1 pg/ml | 687.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | APOL1 | FNab00503 | anti- APOL1 antibody | human | monoclonal | Mouse | apolipoprotein L, 1 | IgG2a | Unconjugated | ELISA, WB, IHC, FC | 100µg | O14791 | RUO | |
FineTest | APOL1 | FNab00502 | anti- APOL1 antibody | human | polyclonal | Rabbit | apolipoprotein L, 1 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | O14791 | RUO | |
Abbexa | APOL1 | abx037468 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | APOL1 | abx402560 | Apolipoprotein L1 (APOL1) Antibody | Human | Monoclonal | Rabbit | Apolipoprotein L1 (APOL1) | Unconjugated | ELISA, FCM | 287.5 | 50 µl | O14791 | RUO | |
Abbexa | APOL1 | abx211265 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O14791 | RUO | |
Abbexa | APOL1 | abx128995 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | O14791 | RUO | |
Abbexa | APOL1 | abx015721 | Apolipoprotein L (APOL1) Antibody | Human | Monoclonal | Mouse | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB | 362.5 | 100 µl | O14791 | RUO | |
Abbexa | APOL1 | abx320433 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | O14791 | RUO | |
Abbexa | APOL1 | abx324418 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | O14791 | RUO | |
Abbexa | APOL1 | abx171290 | Apolipoprotein L (APOL1) Antibody | Human | Monoclonal | Mouse | Apolipoprotein L (APOL1) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | APOL1 | abx432349 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Goat | Apolipoprotein L (APOL1) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | APOL1 | abx014200 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB | 43.75 | 10 µg | O14791 | RUO | |
Abbexa | APOL1 | abx111030 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | O14791 | RUO | |
Abbexa | APOL1 | abx230503 | Apolipoprotein L (APOL1) Antibody | Human | Monoclonal | Mouse | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC, FCM | 350 | 100 µg | O14791 | RUO | |
Abbexa | APOL1 | abx370502 | Apolipoprotein L (APOL1) Antibody Pair | Human | Apolipoprotein L (APOL1) | ELISA | 1462.5 | 5 × 96 tests | RUO | |||||
Abbexa | APOL1 | abx033350 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC, FCM | 250 | 80 µl | O14791 | RUO | |
Abbexa | APOL1 | abx033351 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | O14791 | RUO | |
Abbexa | APOL1 | abx321607 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC | 237.5 | 50 µl | O14791 | RUO | |
Abbexa | APOL1 | abx339560 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O14791 | RUO | |
Abbexa | APOL1 | abx432350 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Goat | Apolipoprotein L (APOL1) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | APOL1 | abx006585 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | IHC | 175 | 20 µl | O14791 | RUO | |
Abbexa | APOL1 | abx230502 | Apolipoprotein L (APOL1) Antibody | Human | Polyclonal | Rabbit | Apolipoprotein L (APOL1) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | O14791 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | APOL1 | abx168142 | Human Apolipoprotein L (APOL1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO | |
FineTest | APOL1 | P2143 | Recombinant Human APOL1 | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | O14791 | RUO |
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