Apelin Receptor (APLNR) Antibody
195€ (20 µl)
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name
Apelin Receptor (APLNR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx002049
tested applications
ELISA, WB
Description
APLNR Antibody is a Rabbit Polyclonal antibody against APLNR. This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apelin Receptor (APLNR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35414 |
| Gene ID | 187 |
| NCBI Accession | NP_005152.1 |
| Alias | APLNR,angiotensin receptor-like 1,AGTRL1 ,APJ,APJR,angiotensin II receptor-like 1 ,B78,GPCR34 | G-protein coupled receptor APJ,APJR, HG11 |
| Background | Antibody anti-APLNR |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
The Apelin receptor (APLNR), also known as angiotensin receptor-like 1 (APJ), is a G-protein-coupled receptor (GPCR) that binds the apelin peptide ligand. APLNR is involved in numerous physiological processes, particularly in the cardiovascular system, where it regulates heart development, blood pressure, and vascular tone. Apelin signaling via APLNR enhances cardiac contractility and contributes to angiogenesis, promoting the formation of new blood vessels during tissue growth or injury. It plays a protective role in heart failure by reducing cardiac hypertrophy and improving ejection fraction. Additionally, the apelin/APLNR pathway is critical for fluid homeostasis and water balance, as it regulates vasopressin release in the hypothalamus. In the central nervous system, APLNR influences neuroprotection and neurodevelopment, modulating processes like neuronal survival and axon growth. The receptor is also significant in metabolic regulation, as it improves insulin sensitivity and glucose uptake, highlighting its relevance to obesity and type 2 diabetes. Dysregulation of APLNR signaling is associated with hypertension, pulmonary arterial hypertension, and pre-eclampsia, conditions related to abnormal vascular function. Furthermore, it has been implicated in cancer progression, where it enhances tumor angiogenesis and promotes tumor cell migration. APLNR's diverse roles in cardiovascular health, neurobiology, and metabolism make it a promising therapeutic target for cardiovascular disease, diabetes, and cancer.
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Apelin Receptor (APLNR) Antibody
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
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