Apelin Receptor (APLNR) Antibody

Descripción

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.

Background

The Apelin Receptor (APLNR), also known as APJ, is a G protein-coupled receptor. APLNR serves as the receptor for two endogenous ligands: APELIN and ELABELA. It plays a crucial role in early development processes such as gastrulation, the formation of blood vessels, and the morphogenesis of the heart, primarily by acting as a receptor for the APELA hormone. Additionally, APLNR may facilitate the migration of angioblasts toward the embryonic midline, which is the future site of vessel formation, during the process of vasculogenesis. This receptor-ligand interaction is essential for orchestrating these critical developmental events

Background

El receptor de Apelina (APLNR), también conocido como APJ, es un receptor acoplado a proteína G. APLNR sirve como receptor de dos ligandos endógenos: APELIN y ELABELA. Desempeña un papel crucial en los procesos tempranos del desarrollo como la gastrulación, la formación de vasos sanguíneos y la morfogénesis del corazón, principalmente actuando como receptor de la hormona APELA. Además, APLNR puede facilitar la migración de angioblastos hacia la línea media embrionaria, que es el futuro sitio de formación de vasos, durante el proceso de vasculogénesis. Esta interacción receptor-ligando es esencial para orquestar estos eventos críticos del desarrollo.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Apelin Receptor (APLNR)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Purified through a protein A column, followed by peptide affinity purification.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

APLNR

dry ice

availability

Shipped within 5-10 working days.

alias

APLNR,angiotensin receptor-like 1,AGTRL1 ,APJ,APJR,angiotensin II receptor-like 1 ,B78,GPCR34 | G-protein coupled receptor APJ,APJR, HG11

uniprot id

https://www.uniprot.org/uniprotkb/P35414

note

This product is for research use only.

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Mouse Aplnr (Apelin receptor) ELISA Kit

proveedor

FineTest

reference

EM6161

reactivity

mouse

status

RUO

Precio a consultar