AP2 Associated Protein Kinase 1 (AAK1) Antibody
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Pida mas información
935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-AAK1
proveedor
Abbexareference
abx028171Tested Applications
ELISA, WB, IHCreactivity
Mousestatus
RUOclonality
PolyclonalDescripción
Aak1 phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis (By similarity).
Background
AAK1, also known as AP2 Associated Protein Kinase 1, is a serine/threonine protein kinase encoded by the AAK1 gene. It is part of the NAK (Numb-Associated Kinase) family of protein kinases and is involved in various cellular processes, including endocytosis, vesicle trafficking, and signaling pathways.AAK1, is involved in endocytosis, vesicle trafficking, and signaling pathways. It regulates clathrin-mediated endocytosis by phosphorylating key components of the endocytic machinery and participates in intracellular vesicle trafficking and signaling cascades. Dysregulation of AAK1 has been implicated in cancer, neurological disorders, and infectious diseases, highlighting its significance as a potential therapeutic target in various pathological conditions. Further research into the molecular mechanisms underlying AAK1 function and its implications for disease may provide insights into novel therapeutic strategies for treating these conditions.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Mouse
immunogen target
AP2 Associated Protein Kinase 1 (AAK1)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified through a protein A column, followed by peptide affinity purification.
recommended dilution
WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AAK1
dry ice
No
availability
Shipped within 5-10 working days.
alias
AAK1,AP2 associated kinase 1
uniprot id
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