AP2 Associated Protein Kinase 1 (AAK1) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
AP2 Associated Protein Kinase 1 (AAK1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028171
tested applications
ELISA, WB, IHC
Description
Aak1 phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AP2 Associated Protein Kinase 1 (AAK1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q3UHJ0 |
| Alias | AAK1,AP2 associated kinase 1 |
| Background | Antibody anti-AAK1 |
| Status | RUO |
Descripción
AAK1, also known as AP2 Associated Protein Kinase 1, is a serine/threonine protein kinase encoded by the AAK1 gene. It is part of the NAK (Numb-Associated Kinase) family of protein kinases and is involved in various cellular processes, including endocytosis, vesicle trafficking, and signaling pathways.AAK1, is involved in endocytosis, vesicle trafficking, and signaling pathways. It regulates clathrin-mediated endocytosis by phosphorylating key components of the endocytic machinery and participates in intracellular vesicle trafficking and signaling cascades. Dysregulation of AAK1 has been implicated in cancer, neurological disorders, and infectious diseases, highlighting its significance as a potential therapeutic target in various pathological conditions. Further research into the molecular mechanisms underlying AAK1 function and its implications for disease may provide insights into novel therapeutic strategies for treating these conditions.
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