UPF3A antibody
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Description
Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | UPF3 regulator of nonsense transcripts homolog A(yeast) (UPF3A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC:1:20-1:200;IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 51 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H1J1 |
| Gene ID | 65110 |
| Alias | Regulator of nonsense transcripts 3A,Nonsense mRNA reducing factor 3A,Up-frameshift suppressor 3 homolog A (hUpf3),UPF3A,RENT3A,UPF3 |
| Background | Antibody anti-UPF3A |
| Status | RUO |
| Note | Mol. Weight 51 kDa |
Descripción
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