UCHL3 antibody
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935106861
info@markelab.com
name
UCHL3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09219
tested applications
ELISA, WB, IHC
Description
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) (UCHL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 26 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P15374 |
| Gene ID | 7347 |
| Alias | UCH-L3,Ubiquitin thioesterase L3 |
| Background | Antibody anti-UCHL3 |
| Status | RUO |
| Note | Mol. Weight 26 kDa |
Descripción
UCHL3 is a deubiquitinating enzyme involved in ubiquitin recycling and protein turnover, ensuring cellular protein quality control and homeostasis. It cleaves ubiquitin precursors and removes ubiquitin chains from target proteins, preventing their premature degradation by the proteasome. UCHL3 is ubiquitously expressed and plays roles in DNA repair, apoptosis, and embryonic development. It is particularly essential for spermatogenesis, where it regulates chromatin remodeling and germ cell differentiation. Loss of UCHL3 function is associated with impaired cellular proteostasis, genomic instability, and reproductive defects. Studies show its involvement in tumor progression, where dysregulation of UCHL3 alters protein degradation pathways, contributing to cancer cell survival. Knockout models exhibit defects in germ cell development, growth retardation, and increased sensitivity to cellular stress, underscoring its importance in ubiquitin regulation, cellular stability, and reproductive biology.
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