TRIM37 antibody
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Description
E3 ubiquitin-protein ligase required to prevent centriole reduplication(PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication(PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A(H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group(PcG) multiprotein PRC2-like complex and mediates repression of target genes(PubMed:25470042). Has anti-HIV activity(PubMed:24317724).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | tripartite motif-containing 37 (TRIM37) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 100kDa, 130kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O94972 |
| Gene ID | 4591 |
| Alias | E3 ubiquitin-protein ligase TRIM37,Mulibrey nanism protein,RING-type E3 ubiquitin transferase TRIM37,Tripartite motif-containing protein 37,TRIM37,KIAA0898,MUL,POB1 |
| Background | Antibody anti-TRIM37 |
| Status | RUO |
| Note | Mol. Weight 100 kDa, 130 kDa |
Descripción
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