TRIM33 antibody

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935106861
info@markelab.com
name
TRIM33 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08981
tested applications
ELISA, WB

Description

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor(By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade(Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
tripartite motif-containing 33 (TRIM33)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1:200-1:2000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
140-150 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q9UPN9
Gene ID
51592
Alias
E3 ubiquitin-protein ligase TRIM33,Ectodermin homolog,RET-fused gene 7 protein (Protein Rfg7),RING-type E3 ubiquitin transferase TRIM33,Transcription intermediary factor 1-gamma (TIF1-gamma),Tripartite motif-containing protein 33,TRIM33,KIAA1113,RFG7,TIF1G
Background
Antibody anti-TRIM33
Status
RUO
Note
Mol. Weight 140-150 kDa

Descripción

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