TNFSF14 antibody

Este producto es parte de TNFSF14 - TNF superfamily member 14
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935106861
info@markelab.com
name
TNFSF14 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08830
tested applications
ELISA

Description

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
tumor necrosis factor(ligand) superfamily, member 14 (TNFSF14)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
0
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
26 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
O43557
Gene ID
8740
Alias
Tumor necrosis factor ligand superfamily member 14,LTg,CD258,HVEML,LIGHT,Herpes virus entry mediator ligand,Herpesvirus entry mediator ligand
Background
Antibody anti-TNFSF14
Status
RUO
Note
Mol. Weight 26 kDa

Descripción

TNFSF14, also known as LIGHT (Lymphotoxin-like, exhibits inducible expression, competes with herpes simplex virus glycoprotein D for HVEM, a receptor expressed by T lymphocytes), is a member of the tumor necrosis factor (TNF) superfamily. This ligand is pivotal in immune response modulation and is highly expressed by activated T cells, NK (natural killer) cells, and certain myeloid cells. LIGHT interacts with several receptors, including HVEM (Herpes Virus Entry Mediator), LTβR (Lymphotoxin beta receptor), and DcR3 (Decoy receptor 3), each playing a distinct role in immune signaling pathways. LIGHT’s functions are diverse and are integral to immune cell proliferation, differentiation, survival, and inflammation, with its dysregulation linked to several immune and inflammatory diseases, as well as certain cancers.

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