SUPT16H antibody
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Description
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2(casein kinase II).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | suppressor of Ty 16 homolog (SUPT16H) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 140 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y5B9 |
| Gene ID | 6830 |
| Alias | FACT complex subunit SPT16,Chromatin-specific transcription elongation factor 140 kDa subunit,FACT 140 kDa subunit,FACTp140,Facilitates chromatin transcription complex subunit SPT16 (hSPT16),SUPT16H,FACT140,FACTP140 |
| Background | Antibody anti-SUPT16H |
| Status | RUO |
| Note | Mol. Weight 140 kDa |
Descripción
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SUPT16H antibody
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