SIGLEC9 antibody
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935106861
info@markelab.com
name
SIGLEC9 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07863
tested applications
ELISA, WB, IHC
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | sialic acid binding Ig-like lectin 9 (SIGLEC9) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55-60 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y336 |
| Gene ID | 27180 |
| Alias | CD329,CDw329,FOAP-9,siglec-9,OBBP-LIKE |
| Background | Antibody anti-SIGLEC9 |
| Status | RUO |
| Note | Mol. Weight 55-60 kDa |
Descripción
SIGLEC9 is widely expressed on neutrophils, monocytes, and subsets of T cells. It binds preferentially to α2-3-linked sialic acids on glycoproteins and glycolipids. SIGLEC9 plays a dual role in modulating immune responses by dampening excessive inflammation through its ITIM domains and enhancing the clearance of apoptotic cells by phagocytes. This protein is critical in host-pathogen interactions, as many pathogens exploit sialic acid-binding properties to evade immune detection. SIGLEC9 is being explored as a target in inflammatory diseases and cancer due to its role in modulating immune activation and resolution.
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