anti- SH2D2A antibody
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Description
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 domain protein 2A |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 48-52 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NP31 |
| Gene ID | 9047 |
| Alias | SH2D2A,F2771, SCAP, TSAD, VRAP, SH2 domain containing 2A |
| Background | Antibody anti-SH2D2A |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
SH2D2A, also known as SCOP (SH2 domain-containing phosphatase), is an SH2 domain-containing adaptor protein that regulates T-cell receptor (TCR) and cytokine receptor signaling pathways. It is primarily expressed in T cells and other hematopoietic cells, where it modulates immune cell activation, proliferation, and cytokine production. SH2D2A functions by binding to phosphorylated receptors and signaling intermediates, linking TCR activation to downstream pathways like NF-κB, MAPK, and PI3K/Akt. It plays an important role in T-cell activation, survival, and differentiation, particularly during immune responses. Dysregulation of SH2D2A is associated with immune dysfunction, autoimmune diseases, and impaired T-cell responses. Knockout studies demonstrate defects in T-cell activation, reduced cytokine production, and impaired antigen-specific responses, underscoring its role as a critical regulator of TCR signaling and adaptive immunity.
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