SH2 Domain Containing 2A (SH2D2A) Antibody
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Description
Rabbit polyclonal antibody against SH2D2A protein. Immunogen region is Internal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 Domain Containing 2A (SH2D2A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NP31 |
| Alias | SH2D2A,F2771, SCAP, TSAD, VRAP, SH2 domain containing 2A |
| Background | Antibody anti-SH2D2A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
SH2D2A, also known as SCOP (SH2 domain-containing phosphatase), is an SH2 domain-containing adaptor protein that regulates T-cell receptor (TCR) and cytokine receptor signaling pathways. It is primarily expressed in T cells and other hematopoietic cells, where it modulates immune cell activation, proliferation, and cytokine production. SH2D2A functions by binding to phosphorylated receptors and signaling intermediates, linking TCR activation to downstream pathways like NF-κB, MAPK, and PI3K/Akt. It plays an important role in T-cell activation, survival, and differentiation, particularly during immune responses. Dysregulation of SH2D2A is associated with immune dysfunction, autoimmune diseases, and impaired T-cell responses. Knockout studies demonstrate defects in T-cell activation, reduced cytokine production, and impaired antigen-specific responses, underscoring its role as a critical regulator of TCR signaling and adaptive immunity.
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