SH2D1B antibody
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Description
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule(SLAM) family such as CD84, SLAMF1, LY9 and CD244(PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer(NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation(PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling(By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse(PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 domain containing 1B (SH2D1B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 15 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O14796 |
| Gene ID | 117157 |
| Alias | SH2D1B, EAT2 |
| Background | Antibody anti-SH2D1B |
| Status | RUO |
| Note | Mol. Weight 15 kDa |
Descripción
SH2D1B, also known as EAT-2 (EWS-FLI1-activated transcript 2), is an SH2 domain-containing adaptor protein that regulates signaling pathways downstream of SLAM family receptors, particularly in innate immune cells like NK cells, macrophages, and dendritic cells. It binds to SLAM receptors and modulates their signaling, influencing NK cell cytotoxicity, macrophage activation, and cytokine production. SH2D1B promotes immune responses by enhancing IFN-γ production, immune synapse formation, and innate immune cell activation. It functions as a positive regulator of SLAM signaling, in contrast to SH2D1A, which can have inhibitory roles depending on context. Dysregulation of SH2D1B is associated with impaired innate immune responses, susceptibility to infections, and inflammatory disorders. Knockout studies reveal reduced NK cell function, impaired macrophage activation, and defective cytokine responses, highlighting its role in fine-tuning innate immunity and SLAM receptor signaling.
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