SH2 Domain Containing 1B (SH2D1B) Antibody
52€ (10 µg)
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Name
SH2 Domain Containing 1B (SH2D1B) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx014879
Tested Applications
ELISA, IHC
Description
Rabbit polyclonal antibody against SH2D1B protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: SH2 Domain Containing 1B (SH2D1B) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human SH2D1B. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | IHC: 1/50 - 1/100, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14796 |
| Alias | SH2D1B, EAT2 |
| Background | Antibody anti-SH2D1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SH2D1B, also known as EAT-2 (EWS-FLI1-activated transcript 2), is an SH2 domain-containing adaptor protein that regulates signaling pathways downstream of SLAM family receptors, particularly in innate immune cells like NK cells, macrophages, and dendritic cells. It binds to SLAM receptors and modulates their signaling, influencing NK cell cytotoxicity, macrophage activation, and cytokine production. SH2D1B promotes immune responses by enhancing IFN-γ production, immune synapse formation, and innate immune cell activation. It functions as a positive regulator of SLAM signaling, in contrast to SH2D1A, which can have inhibitory roles depending on context. Dysregulation of SH2D1B is associated with impaired innate immune responses, susceptibility to infections, and inflammatory disorders. Knockout studies reveal reduced NK cell function, impaired macrophage activation, and defective cytokine responses, highlighting its role in fine-tuning innate immunity and SLAM receptor signaling.
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