RBL2 antibody
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Description
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | retinoblastoma-like 2(p130) (RBL2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 130 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q08999 |
| Gene ID | 5934 |
| Alias | Retinoblastoma-like protein 2,130 kDa retinoblastoma-associated protein (p130),Retinoblastoma-related protein 2 (RBR-2),pRb2,RBL2,RB2 |
| Background | Antibody anti-RBL2 |
| Status | RUO |
| Note | Mol. Weight 130 kDa |
Descripción
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