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The human RAB genes share structural and biochemical properties with the Ras gene superfamily, and RAB4(synonym: RAB4A) is a small GTPase belonging to this Ras superfamily. Accumulating data suggests an important role for RAB proteins either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from endoplasmic reticulum to the Golgi complex and to secretory vesicles involves the movement of carrier vesicles, a process that appears to involve RAB protein function. RAB4 may also function as regulator along the receptor recycling pathway.
RAB4A, member RAS oncogene family (RAB4A) is a small GTPase that is part of the RAS superfamily, which plays a critical role in regulating intracellular vesicular trafficking and membrane dynamics RAB4A is particularly involved in early endosomal trafficking and recycling, contributing to the movement of endosomes between cellular compartments and facilitating the recycling of receptors and other proteins back to the plasma membrane It plays a role in the regulation of cell surface receptor availability and function, affecting processes like endocytosis, cell signaling, and vesicle trafficking Dysregulation of RAB4A has been associated with various diseases, including cancer, where altered vesicular trafficking can lead to changes in cell growth, adhesion, and migration Furthermore, RAB4A is also implicated in processes such as the immune response and neuronal signaling, making it an important protein for both immune function and cellular communication
Primary Antibodies
polyclonal
human,mouse,rat
RAB4A, member RAS oncogene family
Rabbit
IgG
Unconjugated
liquid
ELISA, WB,IHC,IF
26 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:20-1:200
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
RAB4A
RAB4,HRES1,HRES-1,HRES-1/RAB4,Ras-related protein Rab-4A
This product is for research use only.
The human RAB genes share structural and biochemical properties with the Ras gene superfamily, and RAB4(synonym: RAB4A) ...
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Ver másRAB4A Antibody is a Rabbit Polyclonal antibody against RAB4A. This gene is a member of the largest group in the Ras supe...
175€ (20 µl)
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