RAB5A-Specific antibody
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Description
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB3A, member RAS oncogene family (RAB5A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 25 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P20336 |
| Gene ID | 5864 |
| Alias | RAB5,Ras-related protein Rab-5A |
| Background | Antibody anti-RAB5A |
| Status | RUO |
| Note | Mol. Weight 25 kDa |
Descripción
RAB3A, member RAS oncogene family (RAB3A) is another small GTPase that is primarily involved in regulating vesicular trafficking, particularly in neurons and endocrine cells RAB3A plays a pivotal role in the regulated release of neurotransmitters and hormones through its involvement in synaptic vesicle recycling and exocytosis It is essential for the proper functioning of synapses, where it helps control the fusion of synaptic vesicles with the plasma membrane, allowing for neurotransmitter release and signal transmission between neurons In addition to its function in neurotransmission, RAB3A is also involved in insulin secretion in pancreatic beta cells Dysregulation of RAB3A is associated with neurological disorders, such as epilepsy and neurodegenerative diseases, as well as metabolic disorders like diabetes, where impaired vesicle trafficking and hormone release contribute to disease progression Understanding RAB3A’s role in cellular transport and neurotransmission is critical for developing therapeutic strategies for neurological and metabolic diseases
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RAB5A-Specific antibody
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Ver ProductoRAB5A antibody
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes(PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension(PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan(PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3(By similarity).
Ver ProductoRAB5A-Specific antibody
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. The antibody is specific to RAB5A. It has no cross reaction to RAB5B or RAB5C.
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