RAB5A-Specific antibody
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Name
RAB5A-Specific antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab07039
Tested Applications
ELISA, WB, IHC
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. The antibody is specific to RAB5A. It has no cross reaction to RAB5B or RAB5C.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | RAB5A, member RAS oncogene family (RAB5A) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:3000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 24 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P20339 |
| Gene ID | 5868 |
| Alias | RAB5,Ras-related protein Rab-5A |
| Background | Antibody anti-RAB5A |
| Status | RUO |
| Note | Mol. Weight 24 kDa |
Background
RAB5A, member RAS oncogene family (RAB5A) is another member of the RAB family of small GTPases, playing a crucial role in regulating early endosome dynamics and vesicular trafficking RAB5A is involved in the initiation of endocytosis, controlling the fusion of early endosomes and the processing of internalized material It is essential for receptor-mediated endocytosis, where it helps sort and direct cargo for degradation or recycling within the cell RAB5A also participates in the regulation of cell signaling, including receptor tyrosine kinase signaling, and is involved in maintaining cellular communication and response to external signals Dysregulation of RAB5A activity has been linked to a variety of disorders, including cancer, where aberrant endosomal trafficking can influence tumor progression and metastasis Additionally, RAB5A plays a role in immune responses and the trafficking of immune receptors, further highlighting its importance in both normal cellular processes and disease pathogenesis
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