RAB20 antibody
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935106861
info@markelab.com
name
RAB20 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07003
tested applications
ELISA, WB, IP
Description
Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB20, member RAS oncogene family (RAB20) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 26-29 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NX57 |
| Gene ID | 55647 |
| Alias | Ras-related protein Rab-20 |
| Background | Antibody anti-RAB20 |
| Status | RUO |
| Note | Mol. Weight 26-29 kDa |
Descripción
RAB20, member RAS oncogene family (RAB20) is another small GTPase in the RAB family that plays an essential role in regulating intracellular vesicle transport RAB20 is involved in the movement of vesicles between cellular compartments such as endosomes, lysosomes, and the plasma membrane, contributing to processes like endocytosis and vesicular recycling It helps ensure the proper sorting and trafficking of proteins and lipids to their correct cellular destinations, thereby maintaining cellular homeostasis and regulating key cellular processes like signaling, growth, and differentiation RAB20’s role in regulating vesicular trafficking is also crucial for processes like cytokinesis and cell division, where it helps ensure proper distribution of cellular components during mitosis Additionally, RAB20 has been implicated in controlling immune receptor trafficking, which affects cellular immune responses and inflammation RAB20’s dysfunction can contribute to various diseases, including immune-related disorders and cancers, by disrupting vesicular trafficking, immune signaling, and cellular mobility
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