PTPRO antibody

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
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935106861
info@markelab.com
name
PTPRO antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06946
tested applications
ELISA

Description

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function(By similarity).

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
protein tyrosine phosphatase, receptor type, O (PTPRO)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
0
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q16827
Gene ID
5800
Alias
NPHS6,PTPU2,GLEPP1,PTP-OC,PTP-U2,PTPROT,R-PTP-O,Glomerular epithelial protein 1,Protein tyrosine phosphatase U2,Receptor-type tyrosine-protein phosphatase O
Background
Antibody anti-PTPRO
Status
RUO
Note
This product is for research use only.

Descripción

PTPRO, also known as GLEPP1, is a receptor-type protein tyrosine phosphatase involved in kidney function, immune regulation, and tumor suppression. Structurally, PTPRO contains extracellular Ig-like and fibronectin type III domains, a transmembrane segment, and two intracellular phosphatase domains. PTPRO is highly expressed in podocytes, specialized cells in the kidney glomerulus, where it regulates podocyte cytoskeletal organization and filtration barrier integrity. It also functions in immune cells by modulating signaling pathways related to lymphocyte activation. PTPRO has been identified as a tumor suppressor, as its loss or downregulation is associated with cancers such as lung, breast, and colorectal cancers. In the kidney, PTPRO mutations or dysfunction contribute to glomerular diseases, including nephrotic syndrome. Its role in cell growth regulation and tissue homeostasis underscores its biological importance.

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