PTGES3 antibody
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935106861
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name
PTGES3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06918
tested applications
ELISA, IF, IP, WB, FC
Description
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2(PGH2) to prostaglandin E2(PGE2)(PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway(PubMed:24711448).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | prostaglandin E synthase 3(cytosolic) (PTGES3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:2000; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 21-23 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IF, IP, WB, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q15185 |
| Gene ID | 10728 |
| Alias | P23,TEBP,cPGES,Progesterone receptor complex p23,Telomerase-binding protein p23 |
| Background | Antibody anti-PTGES3 |
| Status | RUO |
| Note | Mol. Weight 21-23 kDa |
Descripción
Prostaglandin E synthase 3 (PTGES3), also known as p23, is a multifunctional protein that acts as a co-chaperone for heat shock protein 90 (HSP90), playing a crucial role in the stabilization and activity of various client proteins, including steroid hormone receptors and kinases. It catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), a lipid mediator involved in inflammation, immune response, and various physiological processes such as fever, pain, and vascular homeostasis. PTGES3 is also essential for the proper functioning of the glucocorticoid receptor complex, regulating its maturation and nuclear translocation. Dysregulation of PTGES3 expression has been implicated in cancer progression, as it influences tumor growth, angiogenesis, and immune evasion through PGE2-mediated signaling pathways. In addition to its roles in prostaglandin biosynthesis and HSP90 client protein stabilization, PTGES3 has been associated with the regulation of transcriptional activity and cellular stress responses, underscoring its diverse biological functions. Its expression is tightly regulated and can be modulated by cellular stress, hormonal signals, and inflammatory stimuli, highlighting its importance in maintaining cellular homeostasis and responding to external cues.
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PTGES3 antibody
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2(PGH2) to prostaglandin E2(PGE2)(PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway(PubMed:24711448).
Ver Producto