PTAFR antibody
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935106861
info@markelab.com
name
PTAFR antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06905
tested applications
ELISA, IHC
Description
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | platelet-activating factor receptor (PTAFR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P25105 |
| Gene ID | 5724 |
| Alias | PTAFR,PAFr,AGEPC receptor |
| Background | Antibody anti-PTAFR |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
PTAFR is a G protein-coupled receptor activated by platelet-activating factor (PAF), a potent phospholipid mediator involved in inflammation, immune responses, and thrombosis. PTAFR is widely expressed on platelets, endothelial cells, leukocytes, and in various tissues, where it mediates diverse inflammatory and immune responses. Upon activation, PTAFR couples to Gq and Gi proteins, leading to calcium mobilization, activation of phospholipase C (PLC), and downstream signaling pathways that promote chemotaxis, cytokine release, and oxidative stress. PTAFR plays a central role in allergic reactions, asthma, cardiovascular dysfunction, and sepsis by amplifying inflammatory cascades and vascular permeability. Dysregulation of PTAFR is associated with chronic inflammatory diseases, ischemic injuries, and immune-related conditions. PTAFR antagonists are being explored as potential therapeutics for asthma, sepsis, and cardiovascular diseases by suppressing excessive PAF-mediated inflammation and thrombosis. Its involvement in inflammation and vascular responses positions PTAFR as a critical target for treating immune and inflammatory disorders.
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