PSMD14 antibody
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Description
Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks(DSBs): acts as a regulator of non-homologous end joining(NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | proteasome(prosome, macropain) 26S subunit, non-ATPase, 14 (PSMD14) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 35 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O00487 |
| Gene ID | 10213 |
| Alias | 26S proteasome non-ATPase regulatory subunit 14,26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1,PSMD14,POH1 |
| Background | Antibody anti-PSMD14 |
| Status | RUO |
| Note | Mol. Weight 35 kDa |
Descripción
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