anti- PHF12 antibody

Background

PHF12 is a transcriptional co-repressor and chromatin-associated protein that contains a PHD domain, which enables it to bind methylated histones, particularly H3K4me2/3. PHF12 is a component of the Sin3A-HDAC complex, which regulates gene expression by promoting histone deacetylation and chromatin condensation. It plays an important role in transcriptional repression, DNA damage repair, and cellular differentiation by silencing specific genes during development. PHF12 is highly expressed in tissues undergoing epigenetic remodeling, such as embryonic stem cells and neuronal tissues, where it modulates processes like neurogenesis and stem cell maintenance. Dysregulation of PHF12 has been linked to developmental abnormalities, neurological disorders, and cancers due to aberrant histone modification and transcriptional repression. Knockdown studies reveal defects in gene silencing, impaired chromatin remodeling, and disrupted differentiation, highlighting its role as a critical regulator of chromatin dynamics and transcriptional control.