anti- PAX2 antibody
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Description
Transcription factor that may have a role in kidney cell differentiation(PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | paired box 2 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q02962 |
| Gene ID | 5076 |
| Alias | FSGS7,PAPRS,PAX-2 |
| Background | Antibody anti-PAX2 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
PAX2 is a transcription factor that plays a crucial role in the development of the urogenital system, central nervous system, and the optic nerve by regulating cell proliferation, differentiation, and survival. PAX2 is highly expressed during nephrogenesis, where it guides the formation of kidney structures, including the ureteric bud and nephrons, and in optic development, where it contributes to retinal and optic nerve patterning. Mutations in PAX2 are linked to renal coloboma syndrome, characterized by kidney malformations, optic nerve hypoplasia, and hearing loss. PAX2 also functions as an oncogene in cancers such as renal cell carcinoma and ovarian cancer, where its aberrant expression promotes cell survival, proliferation, and resistance to apoptosis. Knockout studies in mice reveal impaired kidney development, absent optic nerves, and embryonic lethality, highlighting PAX2's essential roles in organogenesis, tissue morphogenesis, and cell lineage specification.
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