anti- PAG1 antibody
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Precio
Precio a consultar
Antibody anti-PAG1
proveedor
FineTestreference
FNab06112Tested Applications
ELISA, WBreactivity
human,mousestatus
RUOclonality
polyclonalDescripción
Negatively regulates TCR(T-cell antigen receptor)-mediated signaling in T-cells and FCER1(high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Background
Pregnancy Associated Glycoprotein 1 (PAG1) belongs to a family of aspartic proteinases expressed by the placental trophoblasts in ruminant species. PAG1 is secreted into maternal circulation during pregnancy and serves as a marker of placental function and fetal well-being. It plays a role in modulating immune tolerance during pregnancy by potentially interacting with maternal immune cells to prevent rejection of the fetal allograft. PAG1 has been widely studied in veterinary medicine as a non-invasive biomarker for early pregnancy detection in cattle, sheep, and other ruminants. Its expression profile and stability in circulation make it a useful tool in reproductive management.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human,mouse
immunogen target
phosphoprotein associated with glycosphingolipid microdomains 1
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB
observerd MW
50-60 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:500-1:2000
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
PAG1
alias
PAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
uniprot id
note
This product is for research use only.
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