anti- PAG1 antibody
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935106861
info@markelab.com
name
anti- PAG1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06112
tested applications
ELISA, WB
Description
Negatively regulates TCR(T-cell antigen receptor)-mediated signaling in T-cells and FCER1(high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | phosphoprotein associated with glycosphingolipid microdomains 1 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 50-60 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NWQ8 |
| Gene ID | 55824 |
| Alias | PAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
| Background | Antibody anti-PAG1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Pregnancy Associated Glycoprotein 1 (PAG1) belongs to a family of aspartic proteinases expressed by the placental trophoblasts in ruminant species. PAG1 is secreted into maternal circulation during pregnancy and serves as a marker of placental function and fetal well-being. It plays a role in modulating immune tolerance during pregnancy by potentially interacting with maternal immune cells to prevent rejection of the fetal allograft. PAG1 has been widely studied in veterinary medicine as a non-invasive biomarker for early pregnancy detection in cattle, sheep, and other ruminants. Its expression profile and stability in circulation make it a useful tool in reproductive management.
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