P2RY6 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
P2RY6 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab06074
Tested Applications
ELISA, WB
Description
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 45 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q15077 |
| Alias | P2RY6,uridine nucleotide receptor,P2Y6,P2Y ATP receptor 6,P2Y purinoceptor 6,pyrimidinergic receptor P2Y |
| Background | Antibody anti-P2RY6 |
| Status | RUO |
| Note | Mol. Weight 45 kDa |
Background
P2RY6 is a G protein-coupled receptor activated by extracellular UDP (uridine diphosphate) and to a lesser extent UTP, mediating cellular responses to nucleotide release during tissue injury or inflammation. P2RY6 couples primarily to Gq proteins, leading to phospholipase C (PLC) activation, calcium mobilization, and downstream signaling that regulates inflammation, immune responses, and smooth muscle contraction. P2RY6 is widely expressed in immune cells, smooth muscle, and epithelial tissues, where it modulates cytokine production, chemotaxis, and vascular tone. In inflammation, P2RY6 plays a central role in recruiting immune cells and amplifying inflammatory signaling, contributing to diseases such as asthma, arthritis, and colitis. It is also involved in smooth muscle contraction in the vascular and gastrointestinal systems. Dysregulation of P2RY6 signaling is linked to chronic inflammatory diseases, cardiovascular dysfunction, and metabolic disorders. P2RY6 antagonists are being investigated as therapeutic agents for inflammation, asthma, and vascular diseases due to their role in regulating immune and smooth muscle responses.
Productos relacionados
P2Y Purinoceptor 6 (P2RY6) Antibody
P2Y Purinoceptor 6 (P2RY6) Antibody is a Rabbit Polyclonal antibody against P2RY6. The product of this gene belongs to t…
Ver producto
P2Y Purinoceptor 6 (P2RY6) Antibody
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes…
Ver producto
P2Y Purinoceptor 6 (P2RY6) Antibody
P2Y Purinoceptor 6 (P2RY6) Antibody is a Rabbit Polyclonal antibody against Pyrimidinergic Receptor P2Y, G-Protein Coupl…
Ver producto