anti- P2RY13 antibody
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935106861
info@markelab.com
name
anti- P2RY13 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06073
tested applications
ELISA, WB, IHC
Description
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | purinergic receptor P2Y, G-protein coupled, 13 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 45 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9BPV8 |
| Gene ID | 5031 |
| Alias | P2RY13,GPR94,G protein-coupled receptor 86,P2Y purinoceptor 13, purinergic receptor P2Y G-protein coupled 13,purinergic receptor P2Y,FKSG77,GPCR1,GPR86,P2Y13,SP174 |
| Background | Antibody anti-P2RY13 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
P2RY13 is a G protein-coupled receptor primarily activated by ADP and related nucleotides. It couples to Gi proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating downstream cellular responses. P2RY13 is expressed in immune cells, liver, and the central nervous system, where it regulates lipid metabolism, immune responses, and energy homeostasis. In the liver, P2RY13 plays a key role in cholesterol metabolism by mediating the uptake of high-density lipoproteins (HDL), contributing to cholesterol homeostasis. In immune cells, P2RY13 regulates chemotaxis, cytokine production, and inflammation. Dysregulation of P2RY13 has been linked to lipid disorders, atherosclerosis, and inflammatory diseases. Its role in immune and metabolic regulation makes P2RY13 a promising therapeutic target for managing hyperlipidemia, atherosclerosis, and chronic inflammatory conditions. Understanding its signaling mechanisms could provide novel therapeutic avenues for metabolic and immune-related diseases.
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