anti- P2RY13 antibody
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935106861
info@markelab.com
Precio
Precio a consultar
Antibody anti-P2RY13
proveedor
FineTestreference
FNab06073Tested Applications
ELISA, WB, IHCreactivity
human,mousestatus
RUOclonality
polyclonalDescripción
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
Background
P2RY13 is a G protein-coupled receptor primarily activated by ADP and related nucleotides. It couples to Gi proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating downstream cellular responses. P2RY13 is expressed in immune cells, liver, and the central nervous system, where it regulates lipid metabolism, immune responses, and energy homeostasis. In the liver, P2RY13 plays a key role in cholesterol metabolism by mediating the uptake of high-density lipoproteins (HDL), contributing to cholesterol homeostasis. In immune cells, P2RY13 regulates chemotaxis, cytokine production, and inflammation. Dysregulation of P2RY13 has been linked to lipid disorders, atherosclerosis, and inflammatory diseases. Its role in immune and metabolic regulation makes P2RY13 a promising therapeutic target for managing hyperlipidemia, atherosclerosis, and chronic inflammatory conditions. Understanding its signaling mechanisms could provide novel therapeutic avenues for metabolic and immune-related diseases.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human,mouse
immunogen target
purinergic receptor P2Y, G-protein coupled, 13
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB, IHC
observerd MW
45 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
P2RY13
alias
P2RY13,GPR94,G protein-coupled receptor 86,P2Y purinoceptor 13, purinergic receptor P2Y G-protein coupled 13,purinergic receptor P2Y,FKSG77,GPCR1,GPR86,P2Y13,SP174
uniprot id
note
This product is for research use only.
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anti- P2RY13 antibody
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proveedor
FineTestreference
FNab06073Tested Applications
ELISA, WB, IHCreactivity
human,mousestatus
RUOclonality
polyclonalReceptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
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