NUP35 antibody
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Description
This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nucleoporin 35kDa (NUP35) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 35 kDa, 44 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8NFH5 |
| Gene ID | 129401 |
| Alias | MP44,NP44,MP-44,NUP53,35 kDa nucleoporin,Mitotic phosphoprotein 44,Nucleoporin NUP53 |
| Background | Antibody anti-NUP35 |
| Status | RUO |
| Note | Mol. Weight 35 kDa, 44 kDa |
Descripción
Nucleoporin 35 (NUP35) is a component of the nuclear pore complex, which serves as the gateway between the nucleus and the cytoplasm NUP35 plays an essential role in the structural integrity of the nuclear pore and in regulating the trafficking of molecules, particularly RNA and proteins, across the nuclear envelope As a nucleoporin, NUP35 participates in the formation of the nuclear pore complex, which facilitates selective transport and ensures proper cellular signaling and gene expression It also helps maintain nuclear-cytoplasmic communication, influencing cellular processes such as cell division, transcription, and gene regulation Dysregulation of NUP35 has been implicated in several diseases, including cancers and neurodegenerative disorders, where defective nuclear transport and nucleoporin function contribute to disease progression
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